Family Health Watch: Local News
Researchers look for diabetes vaccine in human trials
from KY3 News
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Story Updated: Nov 11, 2008
Some pioneering research in Pittsburgh is working on a potential cure for Type 1 Diabetes. The first human patients with diabetes are now enrolled in this test.
Ryan Cupps turned 18 and signed right up for a study that could change the course of the disease that he's had since he was a little boy, Type 1 Diabetes.
"I check my sugar at least six times a day. That's always the most important thing. Injections -- I usually do about five or six a day," said Cupps.
Cupps is the first human in a study being done at Children's Hospital of Pittsburgh. He's had a series of injections of a vaccine designed to block the autoimmune response that kills insulin-producing beta cells in the pancreas, which causes Type 1 diabetes.
"We want to block the killing of the cells. We want to intervene when there are still some beta cells alive and possibly when there is still the possibility to regenerate new beta cells," said Dr. Massimo Trucco, a diabetes researcher.
As simple as it sounds, the process is complex. Blood is taken from each volunteer, processed in the lab to add the immune blockers, then reinjected into the patient's abdomen, near the pancreas.
It won't cure Cupps' diabetes, because his damage is done, but it has cured mice. And it might one day cure young kids just developing the disease.
"My goal is to see a child with diabetes that can eat his ice cream without problems. But an ice cream in a cone," said Trucco.
"Whether you're the first person doing it or the last person doing it, you're still doing it for a sick group of people and you're helping them all," said Cupps.
Trucco and his team hope to finish up this safety stage of the trial by the end of the year and move onto a larger trial by 2010.
Every year, roughly 13,000 children are diagnosed with Type 1 diabetes in the United States. There are approximately 1 million Americans living with it.


Linda Richardson says ...
On Tuesday, Nov 18 at 12:28 PM
My daughter will soon celebrate her 35th birthday. She has had type 1 diabetes since the age of 8. She has graduated college, has a BSN works full time at Skaggs ER, is maarried with two children. Is there any hope this procedure could be of any help to her? Thank you!