Gyorko homered in both ends and has connected seven times in nine games. His two-run shot helped St. Louis win the opener 3-2.
Mike Trout drove in three runs, and Johnny Giavotella had three hits, including two doubles, and scored three runs.
Three relievers finished, with Seung Hwan Oh getting his fifth save in six chances.
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Timberlake could be heard saying, "Bro, why would you do that?"