Receiver Alshon Jeffery, who hasn't played since he fractured his right hand in Week 5 against the Jaguars, had full participation in practice Friday. The rookie has 14 catches for 184 yards and two touchdowns despite missing four games.
Coach Lovie Smith was asked about the impact of having Jeffery back.
"Huge,'' Smith said. "Alshon was playing great ball. (He's) another big target, another guy for Jason to throw to if it comes to that, another guy with some size to block if we lean more toward the run.''
Offensive coordinator Mike Tice is equally enthused about Jeffery's return.
"We're very happy to see (him) practicing,'' Tice said. "He hasn't had any setbacks and he's taking his reps. It's very encouraging.''
Cutler watch: Quarterback Jay Cutler, who is out for Monday night's game with a concussion, was not on the field with his teammates. Smith did not provide more insight to Cutler's status and wouldn't say whether Cutler would travel with the team to San Francisco.
Doctors strongly discourage players from traveling long distances after suffering a concussion because the air pressure on a flight could aggravate symptoms and prolong recovery time.
Smith was pressed on whether Cutler had passed a concussion test but was being held out as a precaution.
"He's not playing this week and that's about as much as I'm going to go into it with it,'' Smith responded. "He's getting better and we're hopeful for next week.''
Cutler did not make a trip to Carolina in 2010 a week after sustaining a concussion against the Giants.
Harbaugh update: 49ers coach Jim Harbaugh was on the practice field Friday, one day after undergoing a minor procedure for an irregular heartbeat.
"Feeling good,'' Harbaugh said. "Yeah, full-go. Had an irregular heartbeat that they had to do a little procedure — a cardiovert — (to) get it back normal. It's amazing that there's a procedure like that, that gets it back to normal.''
Harbaugh said he had a similar issue with his heart 13 years ago and had a cardiac ablation to correct the problem.
On the line: Rookie defensive end Shea McClellin was ruled out for Monday night's game with a concussion, meaning the Bears will have to fill his spot in the defensive line rotation. Because the 49ers are such a run-oriented team, the plan is to activate Amobi Okoye to play both defensive tackle and defensive end. He has been inactive the last three games.
If Monday night's opponent had been more of a passing team, the Bears would have considered activating pass-rusher Cheta Ozougwu. But Okoye is 37 pounds heavier than Ozougwu and gives the Bears more flexibility against the run.
"Amobi is definitely going to bring us some power up the field,'' defensive end Corey Wootton said. "I definitely look for him to make some big plays.''
Extra points: Brian Urlacher was held out of Friday's practice for rest while defensive tackle Matt Toeaina was held out with a calf injury. … In San Francisco, quarterback Alex Smith was limited coming off a concussion but still is expected to start Monday night.